Of 505 youth aged 4 to 19 years with 1 week or less of antipsychotic medication exposure, 338 were enrolled (66.9%). Of these patients, 272 had at least 1 postbaseline assessment (80.5%), and 205 patients who completed the study (60.7%). Patients had mood spectrum (n = 130; 47.8%), schizophrenia spectrum (n = 82; 30.1%), and disruptive or aggressive behavior spectrum (n = 60; 22.1%) disorders. Fifteen patients who refused participation or were nonadherent served as a comparison group.More on the study in the October 27th New York Times:
... 257 young children and adolescents in New York City and on Long Island added 8 to 15 percent to their weight after taking the pills for less than 12 weeks. The patients, ages 4 to 19, added an average of one to one-and-a-half pounds a week. ........ [The participants'] mean weight at the start of the study period was 118 pounds. But after about 11 weeks, those who took Zyprexa had gained 18.7 pounds; Seroquel, 13.4 pounds; Risperdal, 11.7 pounds; and Abilify, 9.7 pounds. Their waists typically expanded three inches with Zyprexa, and two inches with the others. All but Abilify showed rapid and significant increases in one or more metabolic markers, which can presage adult obesity, hypertension and Type 2 diabetes. The metabolic markers included glucose, insulin, triglycerides and cholesterol.Certainly I'd prefer not to have Charlie taking so many medications. Unfortunately, the current situation calls for Jim and me, as Charlie's parents, to do the things that we think can help him to get through the days. He was agitated and crying when he stepped out the door of the middle school on Thursday. Throughout the day he said "bye bye Pete" and, sometimes, "bye bye Jason"----Jason being the aide currently assigned to Charlie, and Pete being the aide assigned to Charlie at his elementary school. Charlie got very excited when he saw a container of multicolored sprinkles shaped like stars at the supermarket; one of the aides in his elementary school used to buy them just for him (yes, she was too nice) and Pete sometimes kept them in his shorts pocket. Pete and another aide, JP, used to go into the school parking lot and run after Charlie as he rode a bike that had been found at the school.
Thursday, on an early evening bike ride with Jim, Charlie started crying before he got on his bike and cried for most of the ride. But he kept on peddling on and, by the last stretch of the ride, he had stopped crying. Charlie was smiling when he and Jim rode up under a setting sun.